Hydroxychloroquine Impurity 72 Sulfate CAS 2411340-32-2 (free base)
| CAS No. | 2411340-32-2 (free base) |
| Molecular Formula | C27H30Cl2N4O |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Hydroxychloroquine Impurity 72 Sulfate.
Hydroxychloroquine Impurity 72 Sulfate (CAS 2411340-32-2 (free base)) is a certified pharmaceutical impurity reference standard with the molecular formula C27H30Cl2N4OH2O4S and a molecular weight of 595.54 g/mol.
Hydroxychloroquine Impurity 72 Sulfate (C27H30Cl2N4OH2O4S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C27H30Cl2N4O H2O4S |
| Molecular Weight | 595.54 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Hydroxychloroquine Standards
- Hydroxychloroquine Impurity 75 (CAS 100713-49-3)
- Hydroxychloroquine EP Impurity B (CAS 103152-84-7)
- Hydroxychloroquine EP Impurity B Hydrogen sulfate (CAS 103152-84-7(free base))
- Hydroxychloroquine EP Impurity E (CAS 10500-64-8)
- Hydroxychloroquine Impurity 32 (CAS 106007-99-2)
- Hydroxychloroquine Impurity 30 (CAS 1077-74-3)
- Hydroxychloroquine Impurity 53 (CAS 109-83-1)
- Hydroxychloroquine D5 (CAS 118-42-3(Unlabelled))
Recommended Standards
- Tofacitinib Impurity 231 (CAS 2101951-20-4)
- Penicillamine EP Impurity A (CAS 20902-45-8)
- Fosfomycin Impurity 59 (CAS 25460-63-3)
- 2-[(3-aminophenyl)methyl]-1λ6,2-thiazolidine-1,1-dione (CAS 91761-17-0)
- (2E,4Z)-2,4-Hexadien-1-ol (CAS 53384-66-0)
- Methyl pyrazolo[1,5-a]pyrimidine-3-carboxylate (CAS 384861-43-2)
- 3-(2-Fluorophenyl)-6-(trifluoromethyl)picolinic acid (CAS 1214347-61-1)
- tert-butyl 3-methylsulfonyloxy-6-azabicyclo[3.1.1]heptane-6-carboxylate (CAS 2753642-00-9)
- benzyl 4-(benzyloxycarbonylamino)-2,7-diazaspiro[4.4]nonane-2-carboxylate (CAS 2306275-96-5)
- Semaglutide impurity 29 (CAS CATO-C4X-222629)
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